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from Student of the Year Student of the Year is a 2012 Indian Hindi-language coming-of-age romantic comedy-drama. ABCD 2 is one of the most awaited movies of the year 2018. disease in previous clinical studies. The potential use of PG-5 is also associated with the properties of the drug itself. For example, we have found that PG-5 inhibits the enzymatic activity of Rac1, which has been implicated in the induction of migration and metastasis in cancer cells \[[@B28],[@B29]\]. These and other studies in our laboratory demonstrated that PG-5 significantly inhibited the metastasis of cancer cells with no or slight cytotoxicity \[[@B27]\]. Thus, the combination of the use of PG-5 and targeted therapy will be promising for treating diseases caused by cancer cell migration and metastasis.
Conclusions
===========
In summary, we examined the ability of PG-5 to inhibit the invasion and migration of cancer cells in vitro by using different methods, including in the presence and absence of a Matrigel layer, and with or without using the activation of FAK or Src. Here, we showed that PG-5 suppressed cancer cell migration in both the absence and presence of a Matrigel layer and the activation of FAK and Src, respectively. These results demonstrate that PG-5 is a unique anti-migratory compound that acts by different mechanisms. This novel anti-migratory agent may be useful in the prevention and treatment of metastatic diseases in humans.
Abbreviations
=============
F-P3C: 3-Formyl-L-tyrosine; Matrigel: Growth factor-reduced matrix protein; PC-3, Prostate Cancer Cell Line-3; Src: Proto-oncogene tyrosine-protein kinase Src; FAK: Focal adhesion kinase.
Competing interests
===================
The authors declare that they have no competing interests.
Authors' contributions
=======================
YHM performed the experiments and drafted the manuscript. MYC, JCL 0b46394aab
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