. of information i want to put in this document manual honda sfx 50 owner manual pdf honda sfx 50 manual scooter user manual by honda scooter manual pdf honda sfx 50 by james barrett owner manual pdf honda scooter gas guzzi honda scooter manual pdf honda scooter user manual pdf honda scooter manual pdf honda scooter user manual pdf honda scooter manual pdf honda scooter user manual pdf honda scooter manual pdf .The intracellular signal transduction pathways downstream of G-protein coupled receptors are mediated by G-protein coupled receptors that activate phospholipase C (PLC). PLC is a ubiquitous enzyme that hydrolyses membrane phospholipids thereby releasing the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). DAG binds to and activates protein kinase C, while IP3 serves as the second messenger for the calcium signal in the cells.
IP3-receptor mediated calcium signaling are involved in a number of processes in eucaryotic cells, including cell division, hormone secretion, and secretion of neurotransmitters. Calcium release from endoplasmic reticulum stores in cultured intestinal crypt cells triggers secretion of gel-forming mucins and activation of a chloride-dependent chloride channel. Moreover, in acinar cells IP3-induced calcium release can increase exocytosis by activation of an adenylate cyclase-protein kinase A pathway.
PKC, also called protein kinase C, is a serine/threonine kinase activated by calcium and DAG. PKC phosphorylates a large number of substrate proteins.
In eucaryotic cells several PKC isoenzymes have been described. PKC isoenzymes differ in their tissue distribution, mode of activation, substrate specificity, calcium requirements for activation, cellular localization, and function. PKC consists of a core enzyme of 200 kilodaltons with a flexible regulatory or “tail” region of 50-100 kilodaltons. The tail region consists of a “constant region” and a “variable region.” The “constant” region is enriched in proline and glutamic acid amino acids and contains a pseudosubstrate sequence for the core enzyme 0b46394aab