Affinity Designer 1.5.5 ? MAC OS X
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Many operating systems provide a mechanism to bind a process to one or more central processing units (CPUs) so that the process executes only on the assigned CPUs. You can configure CPU affinity in your environment to run Mule in a nonvirtualized multicore server and comply with the number of cores included in your subscription.
MAC has an immense pore that is slightly cation-selective and not voltage-dependent. All MACs function by providing cytochrome c with a transport pathway across the outer membrane. These basic characteristics are independent of Bax and Bak content for MAC. Despite the fundamental similarities in the channel behavior of MAC-Bax and MAC-Bak, these channels differ in several important respects. The concentration of t-Bid needed to induce equivalent levels of MAC activity is much greater in Bak-deficient than in Bax-deficient MEF cells, the assembly of MAC channels is slower in the former cells, and the amount of cytochrome c released by t-Bid treatment is less (Fig. 1D). These results are consistent with those of Wei et al. (58) who report that recombinant t-Bid was much more effective in triggering cytochrome c release in Bax KO mitochondria by comparison with Bak KO mitochondria. These differences might be explained, in part, by Bax having a lower affinity for t-Bid than Bak. But there may be another explanation. There may be higher endogenous levels of Bak than Bax in mitochondria from control (nonapoptotic) cells. Recall that Bak is constitutively expressed on mitochondria, whereas most Bax is normally found in the cytosol and only moves to mitochondria after truncation of Bid. In the MAC induction experiments, mitochondria were isolated from normal (nonapoptotic) cells and then treated with t-Bid. The amount of Bax bound to or resident in the mitochondrial outer membrane under these conditions would be low and could limit MAC formation in the Bak-deficient cells. Thus, even if the affinities of Bax and Bak for t-Bid were similar, very high, Bax-saturating levels of t-Bid might be needed to generate detectable MAC formation in the Bak-deficient mitochondria. Limiting levels of Bax in these mitochondria might also be responsible for the slower pore formation times and inefficient cytochrome c release observed in these cells.
Starting with version 1.5.5, a new property called connectionLimit is provided.When this property is set, it limits the total number of connections allowed.When set, if the limit is reached, the channelCheckoutTimeLimit is used to wait for a connection to become idle.If the time is exceeded, an AmqpTimeoutException is thrown. 2b1af7f3a8