Exaggerated exercise-induced bronchoconstriction in nonasthmatic patients with atopic dermatitis.
This study was designed to examine whether patients with atopic dermatitis have bronchoconstriction after exercise and to investigate whether this condition is related to a specific immunologic factor, exercise-induced release of histamine and/or eosinophil cationic protein. The exercise test was performed in 16 patients with atopic dermatitis and in 30 healthy control subjects. After exercise, the rate of increase in pulmonary function of the patients with atopic dermatitis was significantly higher than that of the control subjects. The increase in pulmonary function values was not significantly related to the baseline values. The degree of pulmonary function impairment was independent of the baseline levels. Furthermore, bronchoconstriction after exercise was accompanied by an increase in the plasma levels of histamine and eosinophil cationic protein. A relationship between the exercise test results and the presence of peripheral blood eosinophilia, as well as a relationship between the levels of histamine and eosinophil cationic protein and the degree of exercise-induced bronchoconstriction, were found. These results show that exercise-induced bronchoconstriction is exaggerated in patients with atopic dermatitis and that this increase in response to exercise is associated with the level of mast cell-derived mediators such as histamine and eosinophil cationic protein.HIV risk behavior and its predictors among prisoners in a university hospital in Turkey.
The purpose of this study is to determine the current risk behaviors and risk predictors of HIV/AIDS in a university hospital in Turkey. HIV status and knowledge of the human immunodeficiency virus (HIV) was investigated in prisoners who were referred for discharge to the prison healthcare center in Istanbul, Turkey. A total of 103 prisoners were included in the study. There was an inverse association between HIV knowledge and a history of injection drug use (p =.024). Injection drug use was the only predictor of a history of blood transfusion (p =.001). The results of this study show that the number of risk behaviors among the prisoners is lower than that of the general population. 0b46394aab