Methods: In this streamlined, randomised, controlled, open-label trial, underway at 177 hospitals in the UK, two hospitals in Indonesia, and two hospitals in Nepal, several possible treatments were compared with usual care in patients hospitalised with COVID-19. Patients were eligible for inclusion in the study if they were admitted to hospital with clinically suspected or laboratory confirmed SARS-CoV-2 infection and had no medical history that might, in the opinion of the attending clinician, put the patient at significant risk if they were to participate in the trial. Eligible and consenting adults were randomly assigned (1:1) to receive either usual standard of care alone (usual care group) or usual standard of care plus colchicine (colchicine group) using web-based simple (unstratified) randomisation with allocation concealment. Participants received colchicine 1 mg after randomisation followed by 500 μg 12 h later and then 500 μg twice a day by mouth or nasogastric tube for 10 days in total or until discharge. Dose frequency was halved for patients receiving a moderate CYP3A4 inhibitor (eg, diltiazem), patients with an estimated glomerular filtration rate of less than 30 mL/min per 1·73m2, and those with an estimated bodyweight of less than 70 kg. The primary outcome was 28-day mortality, secondary endpoints included time to discharge, the proportion of patients discharged from hospital within 28 days, and, in patients not on invasive mechanical ventilation at randomisation, a composite endpoint of invasive mechanical ventilation or death. All analyses were by intention-to-treat. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.
The author joined the Intelligence Corps in 1970 but since retiring from the British Army has been responsible for other books including "Nine Battles to Stanley".This book describes a period with which I'm unfamiliar, and occurring after the Malay problems, but prior to the problems in Vietnam.It sets out in some detail both the immediate history of the problems in terms of the population and the politics of the time in setting up the loose federation of Malaysia.The author follows the campaign through in rough chronology with very little overlap and he appears to have access to many documents and individuals who were involved including Peter de la Billiere, Paddy Ashdown and Julian Thompson. Many wished to remain anonymous, but he has collected them together into a narrative.This is not a book recounting personal exploits, recollections and endeavours. It is much more akin to a collection of the diaries of the battalions involved in the conflict which provides an overview with details added. It is, however, scattered with some personal anecdotes which act as comedy relief.The book is quite intense, but I'm guessing the author didn't have much access to the aggressors diaries, and for those people wishing information to set up skirmish or jungle battles they should find sufficient information in this volume to do so because he quotes actual service people involved, their numbers, weapons, uniform and support available.This book should definitely be seen as "bigging up" the British Army, as there is a lot of drum thumping, but he does mention the lack of support and spares from Whitehall occasionally and the lack of journalistic scrutiny.He does also recount all the battles where soldiers were mentioned in despatches or awarded medals. Only one VC awarded during the whole campaign, because the author believes that there was lots of interference from a resentful superior and rather topically the recipient was Lance Corporal Rambahadur Limbu, 10th Princess Mary's Own Gurkha Rifles.A good read and I recommend it.
Meet Ms. Debra Reynolds, a world history teacher at Wicomico Middle School. She talks about building relationships with her students from day one, and how she finds time for her hobbies (like skydiving and antiquing)!
To understand the implications of the relationships observed among the Denisova individual, the Neanderthals and present-day humans, we fit the D statistics described in the previous sections to a parameterized model of population history. The D statistics for the Denisova individual differ in two important ways from those for the Neanderthal. First, the Denisova individual shares fewer derived alleles with either the French or Han Chinese populations than do the Neanderthals. Second, the Denisova individual shares more derived alleles with the Papuans than do the Neanderthals. We are able to fit the data with a model that assumes the Denisovans are a sister group of Neanderthals with a population divergence time of one-half to two-thirds of the time to the common ancestor of Neanderthals and humans. After the divergence of the Denisovans from Neanderthals, there was gene flow from Neanderthals into the ancestors of all present-day non-Africans. Later there was admixture between the Denisovans and the ancestors of Melanesians that did not affect other non-African populations. This model is illustrated in Fig. 3 and is described in detail in Supplementary Information section 11.
For the first time in its history, the Department conducted all major strategic reviews in an integrated way, aligned with the National Security Strategy. By weaving these documents together, the entire Department is matching resources to goals. 2b1af7f3a8